Learn more about risk and benefits for CHANTIX® (varenicline), a prescription medicine to help adults stop smoking Although the antidepressant Zoloft and the smoking cessation medication Chantix have no known interactions with each other, many people are still concerned about the best way to go about taking these two medications at the same time. Also there is that drug Chantix. At my office we have had patients on it and it really does work. It blocks the receptors in the brain or something so your body doesn't want the cigarettes. We provide full service adult Zoloft Chantix in a meticulously clean environment with state-of-the-art equipment. Dr. Sharp and his staff strive to provide consistently exceptional results whether your treatment requires implants, complicated bridgework, treatment for gum disease, dentures or simply routine restorations. How to use Chantix. Read the Medication Guide provided by your pharmacist before you start taking varenicline and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Hi Becky. Definitely check with your doc. I see mine day after tomorrow as I am now on Wellbutrin and want to know if I can add Chantix to the Wellbutrin. We studied 1,345 people who take Chantix and Zoloft from FDA. Drug interactions are found. See what they are, when they happen and for whom. but I read the post on Chantix and seizures.I've recently been diagnosed with a seizure disorder and epilepsy.it's basically been from a head trauma from about 8 years ago.but the seizures remarkably started around the same time a began taking the drug Chantix to help me stop smoking. Compare Chantix vs. Zoloft, which is better for uses like: Anxiety. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Chantix and Zoloft evenly with 3.4/5. Yes you can. Congratulations for quitting smoking, also! Smoking is a bad idea when you have a mood disorder because it does make you feel worse.